Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
gene fusions
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sir2Transcriptional regulator; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (244 aa)    
Predicted Functional Partners:
nadE
Glutamine-dependent NAD+ synthetase signal peptide protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.946
nadD
Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
   
 0.934
nadV
Nicotinamide phosphoribosyl transferase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG1488; Belongs to the NAPRTase family.
   
 0.930
deoD
Purine nucleoside phosphorylase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0813.
    
 0.930
nadK
Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.925
nudC
Probable NAD diphosphatase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG2816.
  
  0.921
pncA
Bifunctional pyrazinamidase/nicotinamidase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1335.
   
 0.911
pntA
NAD(P) transhydrogenase, alpha subunit; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG3288/TC:3.D.2.2.1.
     
 0.904
pntB
NAD(P) transhydrogenase, beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
    
  0.901
CV_0100
Probable transmembrane NAD(P) transhydrogenase transmembrane protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG3288/TC:3.D.2.2.1.
     
 0.901
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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