Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
birABiotin acetyl-CoA-carboxylase synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (314 aa)    
Predicted Functional Partners:
coaX
Probable transcriptional regulator, Bvg acessory factor; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family.
 
    0.997
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
 
 0.953
tadA
Probable cytidine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
  
    0.921
CV_3452
Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG1214.
  
    0.906
accC
Biotin carboxylase protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
 
 0.872
xthA
Exodeoxyribonuclease III; Identified by sequence similarity; putative; ORF located using Blastx/COG0708.
  
    0.867
exoA
Exodeoxyribonuclease III; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0708.
  
    0.867
CV_0488
Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/TC:1.A.4.1.1.
 
     0.852
CV_3611
Probable bifunctional dGTP-pyrophosphohydrolase/thiamine phosphate synthase; Identified by sequence similarity; putative; ORF located using Blastx/COG0494; Belongs to the Nudix hydrolase family.
  
  
 0.845
CV_0018
Probable biotin carboxylase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0439.
 
  
 0.808
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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