Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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coxACytochrome-c oxidase, subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (545 aa)    
Predicted Functional Partners:
coxB
Cytochrome-c oxidase, subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
 0.999
coxC
Cytochrome-c oxidase, subunit III; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1845/TC:3.D.4.7.1.
 0.999
cyoC
Cytochrome o ubiquinol oxidase, subunit III; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1845/TC:3.D.4.5.1.
 0.994
petB
Ubiquinol-cytochrome c reductase; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
 
 0.994
cyoA
Cytochrome o ubiquinol oxidase, subunit II; Identified by sequence similarity; putative; ORF located using Blastx/COG1622/TC:3.D.4.5.1.
 
 0.985
cyoD
Cytochrome o ubiquinol oxidase subunit IV; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG3125/TC:3.D.4.5.1.
  
 0.978
nuoH
NADH-ubiquinone oxidoreductase, chain H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
  
 
 0.975
CV_1171
Probable cytochrome-c oxidase, subunit III; C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
  
 0.974
ctaB
Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
 
 
 0.973
nuoM
NADH-ubiquinone oxidoreductase, chain M; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG1008/TC:3.D.1.3.1.
  
 
 0.971
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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