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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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cobA2uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (470 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.994
cbiC
precorrin-8X methylmutase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2082.
  
 0.993
cobA1
uroporphyrin-III C-methyltransferase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0007; Belongs to the precorrin methyltransferase family.
 
 
0.978
cysI
Sulfite reductase hemoprotein, beta subunit; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0155.
 
  
 0.965
hemD
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.963
cbiL
Precorrin-2 C20-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A.
 
  
 0.960
cysH
Phosphoadenylyl-sulfate reductase; Reduction of activated sulfate into sulfite.
 
  
 0.954
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.948
cysC
Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate.
  
  
 0.933
hemX
uroporphyrin-III C-methyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/COG2959.
     
 0.916
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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