Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (466 aa)    
Predicted Functional Partners:
metE
5-methyltetrahydropteroyltriglutamate- homocysteine S-methyl; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
 
 
 0.987
CV_0203
Probable 5-methyltetrahydrofolate-homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.952
cysB2
Cystathionine beta-synthase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0517.
  
 0.946
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
  
 0.925
mtaD
Probable atrazine chlorohydrolase; Catalyzes the deamination of 5-methylthioadenosine and S- adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine. Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
 
 
 0.924
metY
O-acetylhomoserine (thiol)-lyase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2873.
     
 0.923
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
 
 
 0.895
CV_3394
Probable cystathionine gamma-lyase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0626.
  
 0.851
cysK
Cysteine synthase; Identified by sequence similarity; putative; ORF located using Blastx/COG0031; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 0.849
CV_3597
Probable cysteine synthase B; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0031.
  
 0.849
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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