Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pncABifunctional pyrazinamidase/nicotinamidase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1335. (210 aa)    
Predicted Functional Partners:
pncB
Nicotinic acid phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family.
 
 
 0.984
nadV
Nicotinamide phosphoribosyl transferase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG1488; Belongs to the NAPRTase family.
  
 
 0.911
sir2
Transcriptional regulator; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.
   
 0.911
deoD
Purine nucleoside phosphorylase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0813.
    
  0.900
CV_1806
Probable hydroxymethylglutaryl-CoA reductase (NADPH2); Identified by sequence similarity; putative; ORF located using Blastx/COG1257.
 
      0.730
CV_1320
Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG1335.
      
 0.663
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
      
 0.662
gntV
Gluconokinase; Identified by sequence similarity; putative; ORF located using Blastx/COG3265.
      0.636
copA
Copper-transporting ATPase copA; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2217/TC:3.A.3.5.1.
 
     0.605
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
      
 0.601
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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