Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
sdaA2L-serine dehydratase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family. (466 aa)    
Predicted Functional Partners:
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.960
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.929
tdcB
Threonine dehydratase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG1171.
  
 
 0.924
cysB2
Cystathionine beta-synthase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0517.
  
 
 0.922
cysE
Serine O-acetyltransferase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG1045.
     
 0.917
dsdA
D-serine dehydratase; Identified by sequence similarity; putative; ORF located using Blastx/COG3048; Belongs to the serine/threonine dehydratase family. DsdA subfamily.
     
 0.916
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
   
 
 0.913
serB
Phosphoserine phosphatase; Identified by sequence similarity; putative; ORF located using Blastx/COG0560.
   
 
 0.910
sdaA1
L-serine dehydratase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
  
 
0.904
pssA
CDPdiacylglycerol-serine O-phosphatidyltransferase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1502.
     
  0.900
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.