Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cobDCobalamin biosynthetic protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (312 aa)    
Predicted Functional Partners:
cobQ
Cobyric acid synthase protein; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
 0.996
cobC
Cobalamin biosynthetic protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0079.
 
  
 0.995
cobU
Bifunctional adenosylcobalamin biosynthesis protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.
 
 
 0.984
btuR
cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.
 
  
 0.980
cobD-2
Probable cobalamin biosynthesis transmembrane protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
  
  
 
0.922
CV_2911
Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG2096; Belongs to the Cob(I)alamin adenosyltransferase family.
    
 0.916
cobB
Cobyrinic acid A,C-diamide synthase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1797.
  
 0.904
cbiD
Cobalamin biosynthesis cbiD transmembrane protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.890
cbiJ
precorrin-3B C17-methyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/COG1010.
 
  
 0.882
cbiC
precorrin-8X methylmutase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2082.
 
  
 0.882
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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