Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dnaXDNA polymerase subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (639 aa)    
Predicted Functional Partners:
holB
DNA-directed DNA polymerase III, delta subunit; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0470.
 
 
0.994
dnaN
DNA-directed DNA polymerase, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for init [...]
 
 
 0.992
dnaE
DNA-directed DNA polymerase III, alpha subunit; Identified by sequence similarity; putative; ORF located using Blastx.
 
 0.992
holA
DNA-directed DNA polymerase, delta subunit; Identified by sequence similarity; putative; ORF located using Blastx/COG1466.
   
 0.990
holC
DNA polymerase III, chi subunit; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2927.
    
 0.988
CV_1611
Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
 
  
 0.980
dnaQ
DNA-directed DNA polymerase, epsilon chain; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.
    
 0.979
CV_2751
Probable exonuclease; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0847.
    
 0.979
CV_1020
Probable DNA-directed DNA polymerase III (epsilon subunit); Identified by sequence similarity; putative; ORF located using Blastx/COG0847.
   
 0.977
CV_2946
Probable DNA polymerase III; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0847.
    
 0.968
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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