Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (262 aa)    
Predicted Functional Partners:
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
 0.998
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
 
  
 0.982
CV_3290
Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0413.
  
  
 
0.926
ilvE
Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
    
 0.919
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0801.
  
 0.918
ilvD
Dihydroxy-acid dehydratase; Identified by sequence similarity; putative; ORF located using Blastx/COG0129; Belongs to the IlvD/Edd family.
     
 0.917
CV_3423
Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx.
 
   
 0.718
nadC
Nicotinate-nucleotide pyrophosphorylase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0157; Belongs to the NadC/ModD family.
     0.706
pcnB
Polynucleotide adenylyltransferase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
  
  
 0.669
dgk
Deoxyguanosine kinase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1428.
       0.655
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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