Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
menGS-adenosylmethionine:2-demethylmenaquinone methyltransferase; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). (159 aa)    
Predicted Functional Partners:
aceA
Isocitrate lyase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2224.
 
  
 0.800
mscL
Large conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
   
  
 0.537
fumA
Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
     
 0.465
rhlE3
ATP-dependent RNA helicase; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA.
    
 
 0.421
rhlE4
ATP-dependent RNA helicase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0513.
    
 
 0.421
rhlE2
ATP-dependent RNA helicase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0513; Belongs to the DEAD box helicase family.
    
 
 0.421
dbpA
ATP-dependent RNA helicase dbpA; Identified by sequence similarity; putative; ORF located using Blastx/COG0513; Belongs to the DEAD box helicase family.
    
 
 0.421
rhlE1
ATP-dependent RNA helicase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0513; Belongs to the DEAD box helicase family.
    
 
 0.421
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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