Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (405 aa)    
Predicted Functional Partners:
pgi2
Glucose-6-phosphate isomerase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0166.
  
 0.982
pgi1
Glucose-6-phosphate isomerase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0166.
  
 0.982
agaY
Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
  
 
 0.957
eno
Phosphopyruvate hydratase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0148.
  
  
 0.953
pykF
Pyruvate kinase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0469; Belongs to the pyruvate kinase family.
 
 
 0.951
tktA
Transketolase 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
  
 0.940
pfkB
Sugar kinase protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0524.
 
 0.936
fbp
Fructose-1,6-bisphosphatase; Identified by sequence similarity; putative; ORF located using Blastx/COG0158.
    
 0.936
manC
Mannose-1-phosphate guanylyltransferase; Identified by sequence similarity; putative; ORF located using Blastx/COG0662; Belongs to the mannose-6-phosphate isomerase type 2 family.
    
 0.933
talA
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
   
 0.929
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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