glnE protein (Chromobacterium violaceum) - STRING interaction network

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glnE

Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (894 aa)

Predicted Functional Partners:

glnD

0.803

glnA

0.718

proA

0.633

CV_2097

0.631

CV_2098

0.619

hrpA

0.594

CV_2096

0.591

ilvE

0.578

gltB

0.561

nifS

0.553

Your Current Organism:

Chromobacterium violaceum

NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CV_2096	CV_2097	CV_2096	CV_2097	Probable transmembrane protein; Identified by sequence similarity; putative; ORF located using Blastx/COG3164.	Probable nitrilase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0388.	0.824
CV_2096	CV_2098	CV_2096	CV_2098	Probable transmembrane protein; Identified by sequence similarity; putative; ORF located using Blastx/COG3164.	Probable tldD protein family; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0312.	0.833
CV_2096	glnE	CV_2096	CV_2095	Probable transmembrane protein; Identified by sequence similarity; putative; ORF located using Blastx/COG3164.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.591
CV_2096	ilvE	CV_2096	CV_2094	Probable transmembrane protein; Identified by sequence similarity; putative; ORF located using Blastx/COG3164.	Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.440
CV_2097	CV_2096	CV_2097	CV_2096	Probable nitrilase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0388.	Probable transmembrane protein; Identified by sequence similarity; putative; ORF located using Blastx/COG3164.	0.824
CV_2097	CV_2098	CV_2097	CV_2098	Probable nitrilase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0388.	Probable tldD protein family; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0312.	0.800
CV_2097	glnE	CV_2097	CV_2095	Probable nitrilase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0388.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.631
CV_2097	ilvE	CV_2097	CV_2094	Probable nitrilase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0388.	Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.479
CV_2098	CV_2096	CV_2098	CV_2096	Probable tldD protein family; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0312.	Probable transmembrane protein; Identified by sequence similarity; putative; ORF located using Blastx/COG3164.	0.833
CV_2098	CV_2097	CV_2098	CV_2097	Probable tldD protein family; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0312.	Probable nitrilase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0388.	0.800
CV_2098	glnE	CV_2098	CV_2095	Probable tldD protein family; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0312.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.619
CV_2098	ilvE	CV_2098	CV_2094	Probable tldD protein family; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0312.	Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.413
glnA	glnE	CV_3589	CV_2095	Glutamine synthetase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0174.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.718
glnA	gltB	CV_3589	CV_4038	Glutamine synthetase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0174.	Glutamate synthase, large subunit; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0069.	0.984
glnA	proA	CV_3589	CV_4289	Glutamine synthetase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0174.	Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	0.824
glnD	glnE	CV_2917	CV_2095	protein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.803
glnD	gltB	CV_2917	CV_4038	protein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.	Glutamate synthase, large subunit; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0069.	0.650
glnE	CV_2096	CV_2095	CV_2096	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	Probable transmembrane protein; Identified by sequence similarity; putative; ORF located using Blastx/COG3164.	0.591
glnE	CV_2097	CV_2095	CV_2097	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	Probable nitrilase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0388.	0.631
glnE	CV_2098	CV_2095	CV_2098	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	Probable tldD protein family; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0312.	0.619

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