Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nadKProbable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (291 aa)    
Predicted Functional Partners:
recN
DNA repair protein recN; May be involved in recombinational repair of damaged DNA.
    
 0.951
nadE
Glutamine-dependent NAD+ synthetase signal peptide protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.948
nadD
Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
 
 0.939
sir2
Transcriptional regulator; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.
  
 
 0.925
pntA
NAD(P) transhydrogenase, alpha subunit; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG3288/TC:3.D.2.2.1.
     
 0.922
CV_0100
Probable transmembrane NAD(P) transhydrogenase transmembrane protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG3288/TC:3.D.2.2.1.
     
 0.921
pntB
NAD(P) transhydrogenase, beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.914
nudC
Probable NAD diphosphatase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG2816.
     
 0.901
CV_2323
Probable transcriptional regulatory protein, LuxR family; Identified by sequence similarity; putative; ORF located using Blastx/COG2197.
       0.773
CV_2324
Probable two-component sensor; Identified by sequence similarity; putative; ORF located using Blastx/COG0642.
       0.773
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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