Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
folCFolylpolyglutamate synthase/dihydrofolate synthase; Identified by sequence similarity; putative; ORF located using Blastx/COG0285; Belongs to the folylpolyglutamate synthase family. (421 aa)    
Predicted Functional Partners:
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 0.997
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.947
folA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.928
dedD
Lipoprotein; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/TC:2.C.1.1.1.
  
    0.912
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0801.
  
 0.909
folB
Dihydroneopterin aldolase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1539.
  
  
 0.878
folE
GTP cyclohydrolase I protein; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0302.
 
  
 0.868
CV_2516
Probable colicin V production protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1286.
  
  
 0.829
coaE
Probable dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
  
 0.809
kdtB
Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
  
   
 0.798
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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