node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CV_3095 | CV_3536 | CV_3095 | CV_3536 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2921; Belongs to the UPF0250 family. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG2976. | 0.408 |
CV_3095 | CV_4151 | CV_3095 | CV_4151 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2921; Belongs to the UPF0250 family. | Probable PhoH-related protein; Identified by sequence similarity; putative; ORF located using Blastx/COG1702. | 0.500 |
CV_3095 | apaH | CV_3095 | CV_4067 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2921; Belongs to the UPF0250 family. | Bis(5'-nucleosyl)-tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | 0.451 |
CV_3095 | dacC | CV_3095 | CV_3094 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2921; Belongs to the UPF0250 family. | D-ala-D-ala-carboxypeptidase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1686; Belongs to the peptidase S11 family. | 0.632 |
CV_3095 | grpE | CV_3095 | CV_1642 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2921; Belongs to the UPF0250 family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.469 |
CV_3095 | lipA | CV_3095 | CV_3097 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2921; Belongs to the UPF0250 family. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.835 |
CV_3095 | lipB | CV_3095 | CV_3096 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2921; Belongs to the UPF0250 family. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.896 |
CV_3095 | lnt | CV_3095 | CV_4154 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2921; Belongs to the UPF0250 family. | Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. | 0.437 |
CV_3095 | rlpB | CV_3095 | CV_0506 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2921; Belongs to the UPF0250 family. | Rare lipoprotein B precursor; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane; Belongs to the LptE lipoprotein family. | 0.409 |
CV_3536 | CV_3095 | CV_3536 | CV_3095 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG2976. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2921; Belongs to the UPF0250 family. | 0.408 |
CV_3536 | apaH | CV_3536 | CV_4067 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG2976. | Bis(5'-nucleosyl)-tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | 0.478 |
CV_3536 | rlpB | CV_3536 | CV_0506 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG2976. | Rare lipoprotein B precursor; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane; Belongs to the LptE lipoprotein family. | 0.608 |
CV_4151 | CV_3095 | CV_4151 | CV_3095 | Probable PhoH-related protein; Identified by sequence similarity; putative; ORF located using Blastx/COG1702. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2921; Belongs to the UPF0250 family. | 0.500 |
CV_4151 | lnt | CV_4151 | CV_4154 | Probable PhoH-related protein; Identified by sequence similarity; putative; ORF located using Blastx/COG1702. | Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. | 0.902 |
apaH | CV_3095 | CV_4067 | CV_3095 | Bis(5'-nucleosyl)-tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2921; Belongs to the UPF0250 family. | 0.451 |
apaH | CV_3536 | CV_4067 | CV_3536 | Bis(5'-nucleosyl)-tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG2976. | 0.478 |
dacC | CV_3095 | CV_3094 | CV_3095 | D-ala-D-ala-carboxypeptidase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1686; Belongs to the peptidase S11 family. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2921; Belongs to the UPF0250 family. | 0.632 |
dacC | lipA | CV_3094 | CV_3097 | D-ala-D-ala-carboxypeptidase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1686; Belongs to the peptidase S11 family. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.607 |
dacC | lipB | CV_3094 | CV_3096 | D-ala-D-ala-carboxypeptidase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1686; Belongs to the peptidase S11 family. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.699 |
grpE | CV_3095 | CV_1642 | CV_3095 | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2921; Belongs to the UPF0250 family. | 0.469 |