Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
vioAvioA - tryptophan 2-monooxygenase; The enzyme generates the imine form of indole 3-pyruvate (IPA) from L-tryptophan (L-Trp), with concomitant two-electron reduction of O(2) to H(2)O(2). (418 aa)    
Predicted Functional Partners:
vioB
VioB - polyketide synthase; Catalyzes the hydrogen peroxide-dependent dimerization of two L-tryptophan-derived molecules (imine form of indole 3-pyruvate (IPA)), to form an uncharacterized product suggested to be indole-3-pyruvate imine dimer that can spontaneously convert into dichlorochromopyrrolate (CPA). The uncharacterized product is the substrate of VioE.
    
 0.986
CV_3270
Hypothetical protein.
    
 0.976
vioD
vioD - hydroxylase; Catalyzes the oxygenation of the 6-position of protodeoxyviolaceinate to form proviolacein.
     
 0.855
vioC
vioC monooxygenase; Catalyzes the hydroxylation of the 16-position of protoviolaceinate and protodeoxyviolaceinate to form violacein and deoxyviolacein, respectively.
     
 0.841
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
 0.839
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.800
cviR
Transcriptional activator, LuxR/UhpA family of regulators; Identified by sequence similarity; putative; ORF located using Blastx/COG2771.
      
 0.646
cviI
N-acyl homoserine synthase; Identified by sequence similarity; putative; ORF located using Blastx/COG3916.
      
 0.643
tnaA
Tryptophanase; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG3033; Belongs to the beta-eliminating lyase family.
      
 0.494
bglB
Beta-glucosidase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG2723; Belongs to the glycosyl hydrolase 1 family.
      
 0.493
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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