Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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fumAFumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (508 aa)    
Predicted Functional Partners:
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 
 0.994
sdhA
Succinate dehydrogenase, flavoprotein subunit; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1053; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
 
 0.992
frdA
Fumarate reductase flavoprotein subunit; Identified by sequence similarity; putative; ORF located using Blastx/COG1053.
  
 
 0.992
sdhB
Succinate dehydrogenase iron-sulfur protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0479; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 
 0.990
frdB
Fumarate reductase, subunit B; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0479.
  
 
 0.990
gcvP
Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
  
 0.988
sdhD
Succinate dehydrogenase, hydrophobic subunit; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG2142.
  
 
 0.986
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
 0.984
sdhC
Succinate dehydrogenase cytochrome b-556 subunit; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG2009.
  
 
 0.983
maeB
NADP-dependent malate dehydrogenase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0281.
 
 
 0.978
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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