node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KLO34275.1 | coaX | ABW17_26500 | ABW17_04030 | Nucleoside triphosphate hydrolase; Functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.747 |
KLO36977.1 | coaA | ABW17_22055 | ABW17_22970 | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate kinase; Catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.930 |
KLO36977.1 | coaD | ABW17_22055 | ABW17_00855 | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.979 |
KLO36977.1 | coaX | ABW17_22055 | ABW17_04030 | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.894 |
KLO36977.1 | panC | ABW17_22055 | ABW17_04040 | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.923 |
KLO36977.1 | panD | ABW17_22055 | ABW17_04035 | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Aspartate decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.550 |
KLO36977.1 | tmk | ABW17_22055 | ABW17_04535 | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.667 |
KLO46476.1 | KLO46481.1 | ABW17_04020 | ABW17_04045 | Nucleoid-associated protein Lsr2; Derived by automated computational analysis using gene prediction method: Protein Homology. | Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.744 |
KLO46476.1 | coaX | ABW17_04020 | ABW17_04030 | Nucleoid-associated protein Lsr2; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.744 |
KLO46476.1 | lysS-2 | ABW17_04020 | ABW17_04025 | Nucleoid-associated protein Lsr2; Derived by automated computational analysis using gene prediction method: Protein Homology. | lysyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.583 |
KLO46476.1 | panC | ABW17_04020 | ABW17_04040 | Nucleoid-associated protein Lsr2; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.744 |
KLO46476.1 | panD | ABW17_04020 | ABW17_04035 | Nucleoid-associated protein Lsr2; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.744 |
KLO46481.1 | KLO46476.1 | ABW17_04045 | ABW17_04020 | Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Nucleoid-associated protein Lsr2; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.744 |
KLO46481.1 | coaX | ABW17_04045 | ABW17_04030 | Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.945 |
KLO46481.1 | lysS-2 | ABW17_04045 | ABW17_04025 | Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | lysyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.905 |
KLO46481.1 | panC | ABW17_04045 | ABW17_04040 | Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.995 |
KLO46481.1 | panD | ABW17_04045 | ABW17_04035 | Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aspartate decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.924 |
coaA | KLO36977.1 | ABW17_22970 | ABW17_22055 | Pantothenate kinase; Catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.930 |
coaA | coaD | ABW17_22970 | ABW17_00855 | Pantothenate kinase; Catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.935 |
coaA | coaX | ABW17_22970 | ABW17_04030 | Pantothenate kinase; Catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.911 |