STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
serpini1Serpin peptidase inhibitor, clade I (neuroserpin), member 1; Belongs to the serpin family. (460 aa)    
Predicted Functional Partners:
plg
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
    
 0.619
habp2
Hyaluronan binding protein 2.
   
 0.575
ENSCSEP00000019563
Uncharacterized protein.
   
 0.575
hgfac
HGF activator.
   
 0.484
tmco4
Transmembrane and coiled-coil domains 4.
      
 0.482
ENSCSEP00000001081
Uncharacterized protein.
   
 
  0.477
vtn
Vitronectin a.
   
 0.475
LOC103395458
Vitronectin b.
   
 0.475
atp6ap2
ATPase H+ transporting accessory protein 2.
   
 0.447
LOC103389758
Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
   
 0.444
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
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