node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEM44771.1 | SEN28037.1 | SAMN04488003_101150 | SAMN04488003_11283 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | 0.944 |
SEM44771.1 | fhs | SAMN04488003_101150 | SAMN04488003_11460 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.448 |
SEM44771.1 | folD | SAMN04488003_101150 | SAMN04488003_11459 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.850 |
SEM44771.1 | glyA | SAMN04488003_101150 | SAMN04488003_101303 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.874 |
SEM44771.1 | purH | SAMN04488003_101150 | SAMN04488003_102125 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.992 |
SEM68694.1 | SEN28037.1 | SAMN04488003_103123 | SAMN04488003_11283 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | 0.859 |
SEM68694.1 | fhs | SAMN04488003_103123 | SAMN04488003_11460 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.648 |
SEM68694.1 | fmt | SAMN04488003_103123 | SAMN04488003_103182 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.579 |
SEM68694.1 | folD | SAMN04488003_103123 | SAMN04488003_11459 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.952 |
SEM68694.1 | glyA | SAMN04488003_103123 | SAMN04488003_101303 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.439 |
SEM68694.1 | purH | SAMN04488003_103123 | SAMN04488003_102125 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.520 |
SEN28037.1 | SEM44771.1 | SAMN04488003_11283 | SAMN04488003_101150 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.944 |
SEN28037.1 | SEM68694.1 | SAMN04488003_11283 | SAMN04488003_103123 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.859 |
SEN28037.1 | SEN45479.1 | SAMN04488003_11283 | SAMN04488003_11724 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.622 |
SEN28037.1 | fhs | SAMN04488003_11283 | SAMN04488003_11460 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.951 |
SEN28037.1 | fmt | SAMN04488003_11283 | SAMN04488003_103182 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.899 |
SEN28037.1 | folD | SAMN04488003_11283 | SAMN04488003_11459 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.944 |
SEN28037.1 | glyA | SAMN04488003_11283 | SAMN04488003_101303 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.959 |
SEN28037.1 | purH | SAMN04488003_11283 | SAMN04488003_102125 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.999 |
SEN28037.1 | purU | SAMN04488003_11283 | SAMN04488003_103184 | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.881 |