Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
PE35PE family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable). Plays a role in DNA conjugation, in at least a donor strain. (97 aa)    
Predicted Functional Partners:
esxB
Conserved hypothetical protein; An exported protein. Plays a role in DNA conjugation, in at least a donor strain ; Belongs to the WXG100 family. CFP-10 subfamily.
     
 0.908
espE
Hypothetical protein; Identified by Glimmer2; putative.
     
 0.889
ABK72515.1
Identified by match to protein family HMM PF00903.
      
 0.806
ABK74831.1
Helix-turn-helix domain protein; Identified by match to protein family HMM PF01381.
      
 0.806
espG1
Conserved hypothetical protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Specific chaperone for cognate PE/PPE proteins, plays an important role in preventing aggregation of PE/PPE dimers (By similarity). Also plays a role in DNA conjugation, in at least recipient strain (By similarity). ECO:0000250|UniProtKB:L8FPI5, ; Belongs to the EspG family.
     
 0.792
eccCb1
Ftsk/spoiiie family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Plays a role in DNA conjugation, in both donor and recipient strains.
     
 0.786
ABK74495.1
Identified by match to protein family HMM PF01580.
     
 0.776
mycP1
Membrane-anchored mycosin mycp1; May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Belongs to the peptidase S8 family.
      
 0.756
ABK72095.1
Hypothetical protein; Identified by Glimmer2; putative.
     
 0.740
ABK70762.1
Ppe family protein; Identified by match to protein family HMM PF00823.
     
 0.735
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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