Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
esxAEarly secretory antigenic target, 6 kDa; An exported protein. Unlike its M.tuberculosis counterpart has poor pore forming ability in artificial liposomes, does not undergo conformational change at acidic pH. Mutation of 2 residues to those found in M.tuberculosis (25-TA-26 to IH) alters the properties of this protein so that it inserts into liposomes at acidic pH, forming pores, like its M.tuberculosis counterpart. (95 aa)    
Predicted Functional Partners:
esxB
Conserved hypothetical protein; An exported protein. Plays a role in DNA conjugation, in at least a donor strain ; Belongs to the WXG100 family. CFP-10 subfamily.
  
 0.999
esxH
Low molecular weight protein antigen 7; Belongs to the WXG100 family. ESAT-6 subfamily.
   
 
 0.990
esxG
Pe family protein; Belongs to the WXG100 family. CFP-10 subfamily.
   
 0.989
ABK74158.1
Conserved hypothetical protein; Belongs to the WXG100 family.
  
 0.958
ABK75161.1
Conserved hypothetical protein; Identified by match to protein family HMM PF06013; Belongs to the WXG100 family.
  
 0.906
eccCb1
Ftsk/spoiiie family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Plays a role in DNA conjugation, in both donor and recipient strains.
  
 
 0.902
espE
Hypothetical protein; Identified by Glimmer2; putative.
  
 
 0.888
ABK72627.1
Conserved hypothetical protein; Belongs to the WXG100 family.
     
 0.840
ABK75825.1
Conserved hypothetical protein; Belongs to the WXG100 family.
     
 0.839
ABK70762.1
Ppe family protein; Identified by match to protein family HMM PF00823.
  
  
 0.817
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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