Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
aacAminoglycoside 2'-N-acetyltransferase (AAC(2')-Id); Catalyzes the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides. It confers resistance to aminoglycosides; Belongs to the AAC(2')-I acetyltransferase family. (210 aa)    
Predicted Functional Partners:
ABK75339.1
Allophanate hydrolase subunit 2; Identified by match to protein family HMM PF02626; match to protein family HMM TIGR00724.
  
  
 0.902
ABK73152.1
Allophanate hydrolase subunit 1; Identified by match to protein family HMM PF02682.
  
  
 0.799
ABK70370.1
Cyclic nucleotide-binding protein; Catalyzes specifically the acetylation of the epsilon-amino group of a highly conserved lysine residue in acetyl-CoA synthetase (ACS) and of the universal stress protein (USP) MSMEG_4207. Acetylation results in the inactivation of ACS activity and could be important for mycobacteria to adjust to environmental changes.
  
   
 0.682
mmpL11
MmpL11 protein; Contributes to cell wall biosynthesis and biofilm formation. Transports the mycolic acid-containing lipids monomeromycolyl diacylglycerol (MMDAG) and mycolate ester wax (WE) to the bacterial surface.
  
   
 0.674
whiB7
Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity). Participates in maintaining a reduced cytoplasmic (MSH/MSSM) environment under normal growth conditions and directly or indirectly controls the concentration of mycothiol (MSH + MSSM).
   
  
 0.621
ABK73217.1
Conserved hypothetical protein.
  
     0.582
ABK73502.1
Identified by match to protein family HMM PF01903.
 
     0.558
ABK76086.1
Nitrite extrusion protein; Identified by match to protein family HMM PF07690.
       0.554
ABK73731.1
Amino-acid acetyltransferase; Identified by match to protein family HMM PF00583.
      
 0.550
ABK71591.1
Periplasmic binding protein; Identified by match to protein family HMM PF01497.
 
     0.542
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.