Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ABK72728.1Succinic semialdehyde dehydrogenase; Identified by match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. (484 aa)    
Predicted Functional Partners:
gabT
4-aminobutyrate transaminase; Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00700; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.970
sucA
2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...]
  
 0.959
fumC
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.951
mqo
Malate:quinone-oxidoreductase; Identified by match to protein family HMM PF01266; match to protein family HMM PF06039; match to protein family HMM TIGR01320.
  
 
 0.945
ABK76139.1
Pyruvate synthase; Identified by match to protein family HMM PF01855.
   
 0.941
pckG
Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
   
 
 0.932
gabT-3
4-aminobutyrate transaminase; Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00700; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.931
orB
Alpha oxoglutarate ferredoxin oxidoreductase, beta subunit; Identified by match to protein family HMM PF02775.
    
 0.930
ABK69615.1
Isocitrate dehydrogenase, NADP-dependent; Identified by match to protein family HMM PF03971; match to protein family HMM TIGR00178; Belongs to the monomeric-type IDH family.
     
 0.927
gltA
Citrate synthase I; Identified by similarity to SP:P42457; match to protein family HMM PF00285; match to protein family HMM TIGR01798; Belongs to the citrate synthase family.
  
 0.898
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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