Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rip2Identified by match to protein family HMM PF02163. (259 aa)    
Predicted Functional Partners:
ksgA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
     
 0.810
rip1
Zinc metalloprotease; A probable intramembrane site-2 protease (S2P) that cleaves type-2 transmembrane proteins within their membrane-spanning domains. Degrades PbpB (PBP3, FtsI) under conditions of oxidatives stress; degradation is inhibited by Wag31-PbpB interaction. Also cleaves anti- sigma factors RskA, RslA and RslM. Site-1 proteases have not yet been identified in this organism; Belongs to the peptidase M50B family.
     
 0.805
ABK75690.1
Conserved hypothetical protein.
       0.762
ABK71200.1
Identified by match to protein family HMM PF06737.
      
 0.753
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
    0.577
ABK72994.1
Identified by match to protein family HMM PF03061.
       0.514
ABK75395.1
Conserved hypothetical protein.
  
  
 0.498
ABK74819.1
1-phosphofructokinase; Identified by match to protein family HMM PF00294; Belongs to the carbohydrate kinase PfkB family.
  
    0.413
ABK72535.1
1-phosphofructokinase; Identified by match to protein family HMM PF00294; Belongs to the carbohydrate kinase PfkB family.
  
    0.413
ABK71658.1
6-phosphofructokinase isozyme 2; Identified by match to protein family HMM PF00294; Belongs to the carbohydrate kinase PfkB family.
  
    0.413
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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