| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABK74721.1 | ABK75142.1 | MSMEG_3634 | MSMEG_5270 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | 0.826 |
| ABK74721.1 | ABK75362.1 | MSMEG_3634 | MSMEG_4957 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.409 |
| ABK74721.1 | alr | MSMEG_3634 | MSMEG_1575 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.443 |
| ABK74721.1 | cysE | MSMEG_3634 | MSMEG_5947 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Serine O-acetyltransferase. | 0.439 |
| ABK74721.1 | glyA | MSMEG_3634 | MSMEG_5249 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.725 |
| ABK74721.1 | metH | MSMEG_3634 | MSMEG_4185 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.856 |
| ABK74721.1 | serB | MSMEG_3634 | MSMEG_1041 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Phosphoserine phosphatase; Identified by match to protein family HMM PF00702; match to protein family HMM PF01842; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. | 0.800 |
| ABK74721.1 | trpB | MSMEG_3634 | MSMEG_3220 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.435 |
| ABK75142.1 | ABK74721.1 | MSMEG_5270 | MSMEG_3634 | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | 0.826 |
| ABK75142.1 | ABK75362.1 | MSMEG_5270 | MSMEG_4957 | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.959 |
| ABK75142.1 | alr | MSMEG_5270 | MSMEG_1575 | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.868 |
| ABK75142.1 | cysE | MSMEG_5270 | MSMEG_5947 | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | Serine O-acetyltransferase. | 0.994 |
| ABK75142.1 | glyA | MSMEG_5270 | MSMEG_5249 | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.967 |
| ABK75142.1 | metH | MSMEG_5270 | MSMEG_4185 | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.975 |
| ABK75142.1 | sdaA | MSMEG_5270 | MSMEG_3440 | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | L-serine ammonia-lyase; Identified by similarity to SP:P16095; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.950 |
| ABK75142.1 | serB | MSMEG_5270 | MSMEG_1041 | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | Phosphoserine phosphatase; Identified by match to protein family HMM PF00702; match to protein family HMM PF01842; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. | 0.959 |
| ABK75142.1 | serC | MSMEG_5270 | MSMEG_5684 | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | Phosphoserine aminotransferase, putative; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.836 |
| ABK75142.1 | trpB | MSMEG_5270 | MSMEG_3220 | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.943 |
| ABK75362.1 | ABK74721.1 | MSMEG_4957 | MSMEG_3634 | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | 0.409 |
| ABK75362.1 | ABK75142.1 | MSMEG_4957 | MSMEG_5270 | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | 0.959 |
