Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ABK73930.1Sulfatase; Identified by match to protein family HMM PF00884. (450 aa)    
Predicted Functional Partners:
ABK70975.1
Alpha-galactosidase; Identified by match to protein family HMM PF02056.
     
  0.935
ABK71897.1
Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781.
 
   0.888
ABK75199.1
Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781.
 
   0.835
ABK71307.1
Identified by match to protein family HMM PF00884.
 
  
  0.767
gyrB-2
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
 0.747
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit often mutates to generate rifampicin (Rif) resistance. Interaction with RbpA partially restores Rif-inhibited transcription; once the subunit is Rif-resistant however RbpA no longer stimulates transcription.
   
 
 0.695
ABK75130.1
Arylsulfatase; Identified by match to protein family HMM PF00884.
 
  
 
0.649
ABK74775.1
Transcriptional regulator, GntR family protein; Identified by match to protein family HMM PF00392; match to protein family HMM PF07702.
       0.600
ABK73383.1
Conserved hypothetical protein; Identified by match to protein family HMM PF06742; match to protein family HMM PF06863.
 
     0.578
ABK75140.1
Probable conserved mce associated membrane protein.
   
 0.470
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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