Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
phdHypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the bacteriostatic effect of cognate toxin Doc. In M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions. (65 aa)    
Predicted Functional Partners:
doc
Death-on-curing protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon overexpression causes bacteriostasis. Its effect is neutralized by coexpression with cognate antitoxin PhD. May bind the 30S ribosomal subunit. In M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions.
  
  
 0.965
ABK70576.1
Isochorismatase hydrolase; Identified by match to protein family HMM PF00857.
      
 0.824
ABK73938.1
Isochorismatase hydrolase; Identified by match to protein family HMM PF00857.
      
 0.824
ABK76042.1
Isochorismatase hydrolase; Identified by match to protein family HMM PF00857.
      
 0.823
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
      
 0.805
ABK73370.1
Identified by match to protein family HMM PF01575.
      
 0.763
vapC
PIN domain protein; Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease, cleavage occurs after the first AU in the consensus sequence AUA(U/A); RNA secondary structure is probably important in substrate choice. Cuts in 5' and 3' UTRs. The TA system acts as a post-transcriptional regulator of carbon metabolism; in M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions. When overexpressed inhibits cell growth, [...]
     
 0.678
ABK71227.1
Conserved hypothetical protein.
       0.559
ABK74567.1
Hypothetical cytosolic protein.
       0.559
ABK71736.1
Conserved hypothetical protein.
       0.559
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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