Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ABK72225.15-carboxymethyl-2-hydroxymuconate delta-isomerase; Identified by match to protein family HMM PF01557. (206 aa)    
Predicted Functional Partners:
sucA
2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...]
  
 0.821
ABK69583.1
Fumarylacetoacetate; Identified by match to protein family HMM PF01557.
  
     0.763
ABK72215.1
Fumarate hydratase class I, anaerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
 0.719
ABK76174.1
Major facilitator superfamily protein MFS_1; Identified by match to protein family HMM PF07690.
  
    0.551
fumC
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.548
ABK75093.1
Asp/Glu racemase; Identified by match to protein family HMM PF01177.
       0.544
ABK75757.1
Identified by match to protein family HMM PF01522.
  
    0.539
hmgA
Homogentisate 1,2-dioxygenase; Identified by match to protein family HMM PF04209.
  
  
 0.532
ABK73901.1
Urease gamma/beta subunit; Identified by match to protein family HMM PF00547; match to protein family HMM PF00699; match to protein family HMM TIGR00192; match to protein family HMM TIGR00193.
     
  0.523
ABK73659.1
Identified by match to protein family HMM PF03734.
       0.476
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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