Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mmsAMethylmalonate-semialdehyde dehydrogenase; Identified by similarity to GB:AAA99190.1; match to protein family HMM PF00171; match to protein family HMM TIGR01722. (506 aa)    
Predicted Functional Partners:
mmsB
3-hydroxyisobutyrate dehydrogenase; Identified by match to protein family HMM PF03446; match to protein family HMM PF03807; match to protein family HMM TIGR01692; Belongs to the HIBADH-related family.
 
 
 0.995
ABK74368.1
acyl-CoA dehydrogenase family protein member 8; Identified by match to protein family HMM PF00441; match to protein family HMM PF02770; match to protein family HMM PF02771; match to protein family HMM PF08028.
 
 
 0.959
gabT-3
4-aminobutyrate transaminase; Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00700; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.958
ABK71302.1
6-phosphogluconate dehydrogenase, NAD-binding; Identified by match to protein family HMM PF03446; match to protein family HMM PF03807.
 
 
 0.952
ABK72245.1
6-phosphogluconate dehydrogenase, NAD-binding; Identified by match to protein family HMM PF03446; match to protein family HMM PF03807.
 
 
 0.951
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
 
 
 0.949
ABK76139.1
Pyruvate synthase; Identified by match to protein family HMM PF01855.
   
 0.949
PrpE
propionate--CoA ligase; Identified by match to protein family HMM PF00501.
  
 0.949
ABK72632.1
AMP-dependent synthetase and ligase; Identified by match to protein family HMM PF00501.
  
 0.949
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.949
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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