Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ABK74144.1ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (291 aa)    
Predicted Functional Partners:
ABK72831.1
Fluoroquinolone transport system permease protein; Probable antibiotic-transport integral membrane leucine and alanine and valine rich protein abc transporter.
 
 
 0.997
ABK75242.1
Probable antibiotic-transport integral membrane leucine and valine rich protein abc transporter.
 
 
 0.996
ABK76084.1
ABC-type multidrug transport system ATPase component; Identified by match to protein family HMM PF00005.
 
    
0.877
ABK72530.1
Possible drug efflux membrane protein; Identified by match to protein family HMM PF07690.
  
  
 0.836
ABK76237.1
ABC transporter membrane-spanning protein.
  
 
 0.790
lfrA
Proton antiporter efflux pump; Energy-dependent efflux pump that contributes to drug resistance. Catalyzes the efflux of norfloxacin and several related fluoroquinolones (FQ). Contributes significantly to the intrinsic MICs for ethidium bromide and acriflavine. Overexpression confers low-level resistance to hydrophilic FQ such as ciprofloxacin, ofloxacin and levofloxacin, and to ethidium bromide, acridine, acriflavine, rhodamine 123 and some quaternary ammonium compounds. May contribute to resistance to certain beta-lactams. Probably uses the proton motive force.
    
 
 0.767
ABK72977.1
Methyltransferase, putative, family protein; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
 
    0.699
ABK71448.1
ABC transporter ATP-binding protein; Identified by match to protein family HMM PF00005.
 
0.665
ABK71153.1
ABC-type drug export system, membrane protein; Identified by match to protein family HMM PF01061.
 
 
 0.662
ABK72388.1
Hypothetical ABC transporter ATP-binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00970; match to protein family HMM PF04954; match to protein family HMM PF08021.
 
0.646
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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