Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ABK71634.1Identified by match to protein family HMM PF00899. (723 aa)    
Predicted Functional Partners:
ABK73391.1
Conserved hypothetical protein.
  
  
 0.967
thiS
Thiamine biosynthesis protein ThiS; Identified by match to protein family HMM PF02597; match to protein family HMM TIGR01683.
  
 0.883
ABK69623.1
Sensory box/response regulator; Identified by match to protein family HMM PF00563; match to protein family HMM PF00990; match to protein family HMM PF01590; match to protein family HMM TIGR00254.
 
  
 0.868
moaE
Molybdopterin converting factor, subunit 2; Identified by match to protein family HMM PF02391.
  
 0.860
thiG
Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.817
ABK69833.1
Conserved hypothetical protein.
 
 0.808
ABK74564.1
Transcriptional regulator, TetR family protein; Identified by match to protein family HMM PF00440; match to protein family HMM PF02909.
  
  
 0.785
ABK74504.1
Identified by match to protein family HMM PF02597.
  
 0.714
ABK75127.1
Identified by match to protein family HMM PF02597.
  
 0.714
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
 
 0.695
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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