Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mmsA-2Methylmalonate-semialdehyde dehydrogenase; Identified by match to protein family HMM PF00171; match to protein family HMM TIGR01722. (497 aa)    
Predicted Functional Partners:
mmsB
3-hydroxyisobutyrate dehydrogenase; Identified by match to protein family HMM PF03446; match to protein family HMM PF03807; match to protein family HMM TIGR01692; Belongs to the HIBADH-related family.
 
 
 0.977
gabT-3
4-aminobutyrate transaminase; Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00700; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.958
ABK71302.1
6-phosphogluconate dehydrogenase, NAD-binding; Identified by match to protein family HMM PF03446; match to protein family HMM PF03807.
 
 
 0.952
ABK76139.1
Pyruvate synthase; Identified by match to protein family HMM PF01855.
   
 0.949
PrpE
propionate--CoA ligase; Identified by match to protein family HMM PF00501.
  
 0.949
ABK72632.1
AMP-dependent synthetase and ligase; Identified by match to protein family HMM PF00501.
  
 0.949
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.949
ABK73929.1
Citrate synthase 2; Identified by match to protein family HMM PF00285; match to protein family HMM TIGR01800; Belongs to the citrate synthase family.
  
 0.949
ABK72039.1
Alcohol dehydrogenase; Identified by match to protein family HMM PF00107; match to protein family HMM TIGR02823.
   
 0.948
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 0.948
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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