Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ABK75138.1Identified by match to protein family HMM PF06993. (128 aa)    
Predicted Functional Partners:
ruvC
Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
       0.861
ruvA
Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
       0.861
ruvB
Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
       0.861
ABK74602.1
ABC transporter efflux protein, DrrB family protein; Identified by match to protein family HMM PF01061; match to protein family HMM TIGR00025.
 
   
 0.851
ABK71801.1
ABC transporter ATP-binding protein; Identified by match to protein family HMM PF00005.
  
   
 0.844
ABK70221.1
Transcriptional regulator; Identified by match to protein family HMM PF00440.
      
 0.824
ABK74859.1
Conserved hypothetical protein.
      
 0.761
ABK73305.1
Oxidoreductase, zinc-binding dehydrogenase family protein; Identified by match to protein family HMM PF00107.
     
 0.548
ABK73073.1
Alcohol dehydrogenase, zinc-binding; Identified by match to protein family HMM PF00107.
     
 0.548
ABK75387.1
Glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein; Identified by match to protein family HMM PF00903.
       0.503
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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