| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABK72109.1 | ABK76067.1 | MSMEG_1652 | MSMEG_0239 | O-acetylhomoserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326. | O-acetylhomoserine/O-acetylserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01326. | 0.920 |
| ABK72109.1 | metE | MSMEG_1652 | MSMEG_6638 | O-acetylhomoserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.970 |
| ABK72109.1 | metH | MSMEG_1652 | MSMEG_4185 | O-acetylhomoserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.973 |
| ABK72109.1 | metK | MSMEG_1652 | MSMEG_3055 | O-acetylhomoserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.963 |
| ABK74802.1 | ABK76067.1 | MSMEG_2359 | MSMEG_0239 | Methionine synthase, vitamin-B12 independent; Identified by match to protein family HMM PF01717. | O-acetylhomoserine/O-acetylserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01326. | 0.687 |
| ABK74802.1 | metH | MSMEG_2359 | MSMEG_4185 | Methionine synthase, vitamin-B12 independent; Identified by match to protein family HMM PF01717. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.941 |
| ABK74802.1 | metK | MSMEG_2359 | MSMEG_3055 | Methionine synthase, vitamin-B12 independent; Identified by match to protein family HMM PF01717. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.878 |
| ABK76067.1 | ABK72109.1 | MSMEG_0239 | MSMEG_1652 | O-acetylhomoserine/O-acetylserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01326. | O-acetylhomoserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326. | 0.920 |
| ABK76067.1 | ABK74802.1 | MSMEG_0239 | MSMEG_2359 | O-acetylhomoserine/O-acetylserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01326. | Methionine synthase, vitamin-B12 independent; Identified by match to protein family HMM PF01717. | 0.687 |
| ABK76067.1 | metE | MSMEG_0239 | MSMEG_6638 | O-acetylhomoserine/O-acetylserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01326. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.942 |
| ABK76067.1 | metH | MSMEG_0239 | MSMEG_4185 | O-acetylhomoserine/O-acetylserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01326. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.965 |
| ABK76067.1 | metK | MSMEG_0239 | MSMEG_3055 | O-acetylhomoserine/O-acetylserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01326. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.850 |
| gmk | metK | MSMEG_3051 | MSMEG_3055 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.878 |
| gmk | rpe | MSMEG_3051 | MSMEG_3066 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Ribulose-phosphate 3-epimerase; Identified by similarity to SP:P46969; match to protein family HMM PF00834; match to protein family HMM TIGR01163; Belongs to the ribulose-phosphate 3-epimerase family. | 0.812 |
| metE | ABK72109.1 | MSMEG_6638 | MSMEG_1652 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | O-acetylhomoserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326. | 0.970 |
| metE | ABK76067.1 | MSMEG_6638 | MSMEG_0239 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | O-acetylhomoserine/O-acetylserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM TIGR01326. | 0.942 |
| metE | metH | MSMEG_6638 | MSMEG_4185 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.997 |
| metE | metK | MSMEG_6638 | MSMEG_3055 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.991 |
| metH | ABK72109.1 | MSMEG_4185 | MSMEG_1652 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-acetylhomoserine sulfhydrylase; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326. | 0.973 |
| metH | ABK74802.1 | MSMEG_4185 | MSMEG_2359 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase, vitamin-B12 independent; Identified by match to protein family HMM PF01717. | 0.941 |
