Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cyoEProtoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (308 aa)    
Predicted Functional Partners:
ctaD
Cytochrome c oxidase, subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
 
 0.999
ABK72041.1
Cytochrome aa3 controlling protein; Identified by match to protein family HMM PF02628.
 
 0.998
ABK69740.1
Cytochrome c oxidase subunit 3; Identified by match to protein family HMM PF00510.
 
 
 0.998
ABK74914.1
Cytochrome c oxidase subunit 2; Identified by match to protein family HMM PF00116.
 
 
 0.998
ABK70782.1
Cytochrome c oxidase subunit III family protein; Identified by match to protein family HMM PF00510.
 
 
 0.975
ABK69679.1
Probable cytochrome c oxidase polypeptide 4; Part of cytochrome c oxidase, its function is unknown. Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
  
  
 0.967
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
     
 0.949
ABK71061.1
Conserved hypothetical protein; Identified by match to protein family HMM PF06778.
     
 0.938
ABK74857.1
Pyridoxamine 5'-phosphate oxidase family protein; Identified by match to protein family HMM PF01243.
     
  0.935
ccsB
Cytochrome c-type biogenesis protein CcsB; Identified by match to protein family HMM PF01578; match to protein family HMM TIGR03144.
     
 0.840
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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