| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABK71282.1 | ABK72037.1 | MSMEG_3532 | MSMEG_3309 | Identified by match to protein family HMM PF00291. | Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.937 |
| ABK71282.1 | ABK73212.1 | MSMEG_3532 | MSMEG_2394 | Identified by match to protein family HMM PF00291. | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | 0.957 |
| ABK71282.1 | ABK75142.1 | MSMEG_3532 | MSMEG_5270 | Identified by match to protein family HMM PF00291. | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | 0.959 |
| ABK71282.1 | ABK75362.1 | MSMEG_3532 | MSMEG_4957 | Identified by match to protein family HMM PF00291. | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.680 |
| ABK71282.1 | glyA | MSMEG_3532 | MSMEG_5249 | Identified by match to protein family HMM PF00291. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.955 |
| ABK71282.1 | ilvA | MSMEG_3532 | MSMEG_3183 | Identified by match to protein family HMM PF00291. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.949 |
| ABK71282.1 | sdaA | MSMEG_3532 | MSMEG_3440 | Identified by match to protein family HMM PF00291. | L-serine ammonia-lyase; Identified by similarity to SP:P16095; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.956 |
| ABK71282.1 | thrB | MSMEG_3532 | MSMEG_4955 | Identified by match to protein family HMM PF00291. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.687 |
| ABK71282.1 | trpA | MSMEG_3532 | MSMEG_3221 | Identified by match to protein family HMM PF00291. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.948 |
| ABK71282.1 | trpB | MSMEG_3532 | MSMEG_3220 | Identified by match to protein family HMM PF00291. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.969 |
| ABK72037.1 | ABK71282.1 | MSMEG_3309 | MSMEG_3532 | Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | Identified by match to protein family HMM PF00291. | 0.937 |
| ABK72037.1 | ABK75142.1 | MSMEG_3309 | MSMEG_5270 | Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | 0.935 |
| ABK72037.1 | ABK75362.1 | MSMEG_3309 | MSMEG_4957 | Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.431 |
| ABK72037.1 | glyA | MSMEG_3309 | MSMEG_5249 | Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.943 |
| ABK72037.1 | ilvA | MSMEG_3309 | MSMEG_3183 | Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.969 |
| ABK72037.1 | sdaA | MSMEG_3309 | MSMEG_3440 | Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | L-serine ammonia-lyase; Identified by similarity to SP:P16095; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.950 |
| ABK72037.1 | trpA | MSMEG_3309 | MSMEG_3221 | Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.995 |
| ABK72037.1 | trpB | MSMEG_3309 | MSMEG_3220 | Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.980 |
| ABK73212.1 | ABK71282.1 | MSMEG_2394 | MSMEG_3532 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | Identified by match to protein family HMM PF00291. | 0.957 |
| ABK73212.1 | ABK75142.1 | MSMEG_2394 | MSMEG_5270 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | 0.999 |
