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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ABK70798.1DNA-binding protein. (215 aa)    
Predicted Functional Partners:
ribE-2
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
     
 0.836
metH
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.758
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.677
dehII-2
Haloacid dehalogenase, type II; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01428; match to protein family HMM TIGR01493.
  
    0.559
clpX
ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
   
 
 0.543
ABK74143.1
Riboflavin biosynthesis protein RibD C- domain protein; Identified by match to protein family HMM PF01872.
 
     0.500
ABK75605.1
Conserved hypothetical protein; Identified by match to protein family HMM PF05988.
 
     0.483
sap
Sigma associated protein; Identified by match to protein family HMM PF04946.
 
     0.472
ecf
Extra cytoplasmic sigma factor; Identified by match to protein family HMM PF04542; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family.
 
     0.469
ABK69819.1
Two-component system sensor kinase; Identified by match to protein family HMM PF02518; match to protein family HMM PF07730.
       0.461
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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