| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABK73577.1 | ABK75142.1 | MSMEG_3517 | MSMEG_5270 | HAD-superfamily protein subfamily protein IB hydrolase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | 0.549 |
| ABK73577.1 | ABK75378.1 | MSMEG_3517 | MSMEG_3518 | HAD-superfamily protein subfamily protein IB hydrolase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Conserved hypothetical protein. | 0.550 |
| ABK73577.1 | hisB | MSMEG_3517 | MSMEG_3207 | HAD-superfamily protein subfamily protein IB hydrolase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | 0.511 |
| ABK73577.1 | hisC | MSMEG_3517 | MSMEG_3206 | HAD-superfamily protein subfamily protein IB hydrolase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.528 |
| ABK73577.1 | hisF | MSMEG_3517 | MSMEG_3211 | HAD-superfamily protein subfamily protein IB hydrolase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.585 |
| ABK73577.1 | hisH | MSMEG_3517 | MSMEG_3208 | HAD-superfamily protein subfamily protein IB hydrolase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.525 |
| ABK73577.1 | hisIE | MSMEG_3517 | MSMEG_3212 | HAD-superfamily protein subfamily protein IB hydrolase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.514 |
| ABK73577.1 | metH | MSMEG_3517 | MSMEG_4185 | HAD-superfamily protein subfamily protein IB hydrolase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.746 |
| ABK73577.1 | priA-2 | MSMEG_3517 | MSMEG_3209 | HAD-superfamily protein subfamily protein IB hydrolase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Bifunctional HisA/TrpF protein; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | 0.522 |
| ABK73577.1 | serC | MSMEG_3517 | MSMEG_5684 | HAD-superfamily protein subfamily protein IB hydrolase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Phosphoserine aminotransferase, putative; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.694 |
| ABK75142.1 | ABK73577.1 | MSMEG_5270 | MSMEG_3517 | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | HAD-superfamily protein subfamily protein IB hydrolase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | 0.549 |
| ABK75142.1 | metH | MSMEG_5270 | MSMEG_4185 | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.975 |
| ABK75142.1 | serC | MSMEG_5270 | MSMEG_5684 | Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137. | Phosphoserine aminotransferase, putative; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.836 |
| ABK75378.1 | ABK73577.1 | MSMEG_3518 | MSMEG_3517 | Conserved hypothetical protein. | HAD-superfamily protein subfamily protein IB hydrolase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | 0.550 |
| hisB | ABK73577.1 | MSMEG_3207 | MSMEG_3517 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | HAD-superfamily protein subfamily protein IB hydrolase; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | 0.511 |
| hisB | hisC | MSMEG_3207 | MSMEG_3206 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
| hisB | hisF | MSMEG_3207 | MSMEG_3211 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
| hisB | hisH | MSMEG_3207 | MSMEG_3208 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisB | hisIE | MSMEG_3207 | MSMEG_3212 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
| hisB | priA-2 | MSMEG_3207 | MSMEG_3209 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Bifunctional HisA/TrpF protein; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | 0.999 |
