Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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ABK70348.1Integral membrane protein; Identified by match to protein family HMM PF07681. (136 aa)    
Predicted Functional Partners:
dtd
D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family.
   
   0.734
ABK74175.1
Cation-transporting ATPase Pma1; Identified by match to protein family HMM PF00122; match to protein family HMM PF00689; match to protein family HMM PF00690; match to protein family HMM PF00702; match to protein family HMM TIGR01494.
   
  0.652
ctpE
P-type ATPase - metal cation transport; P-type ATPase involved in specific uptake of calcium. Essential for growth and maintenance of cell surface integrity under Ca(2+)-deficient conditions.
   
  0.652
saeC
Conserved hypothetical protein; May be involved in assembly of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Involved in DNA conjugation in recipient (MKD8) strain.
   
 0.536
ABK74074.1
Conserved hypothetical protein; Identified by match to protein family HMM PF05114.
  
  
 0.490
secY
Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
   
 
 0.482
ABK69904.1
Conserved hypothetical protein.
  
 
 0.468
glnA-2
Glutamine synthetase, type I; Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family.
  
    0.458
eccA1
ATPase, AAA family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Plays a role in DNA conjugation, in both donor and recipient strains. EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (By similarity).
     
 0.433
eccA3
ATPase, AAA family protein; Part of the ESX-3 specialized secretion system, which is required for siderophore-mediated iron acquisition and for the secretion of EsxH and EsxG. EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity).
     
 0.433
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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