| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABK71282.1 | ABK72676.1 | MSMEG_3532 | MSMEG_1516 | Identified by match to protein family HMM PF00291. | Thioredoxin reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00072; match to protein family HMM PF01266; match to protein family HMM PF07992. | 0.444 |
| ABK71282.1 | bioF | MSMEG_3532 | MSMEG_3189 | Identified by match to protein family HMM PF00291. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.442 |
| ABK71282.1 | gcvP | MSMEG_3532 | MSMEG_3642 | Identified by match to protein family HMM PF00291. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.518 |
| ABK71282.1 | gcvT | MSMEG_3532 | MSMEG_4278 | Identified by match to protein family HMM PF00291. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.451 |
| ABK71282.1 | glyA | MSMEG_3532 | MSMEG_5249 | Identified by match to protein family HMM PF00291. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.955 |
| ABK71282.1 | ilvA | MSMEG_3532 | MSMEG_3183 | Identified by match to protein family HMM PF00291. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.949 |
| ABK71282.1 | ltaE | MSMEG_3532 | MSMEG_4454 | Identified by match to protein family HMM PF00291. | L-threonine aldolase, low-specificity; Identified by similarity to SP:O50584; match to protein family HMM PF00282; match to protein family HMM PF01212. | 0.950 |
| ABK71282.1 | sdaA | MSMEG_3532 | MSMEG_3440 | Identified by match to protein family HMM PF00291. | L-serine ammonia-lyase; Identified by similarity to SP:P16095; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.956 |
| ABK71282.1 | thrC | MSMEG_3532 | MSMEG_4956 | Identified by match to protein family HMM PF00291. | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.983 |
| ABK72676.1 | ABK71282.1 | MSMEG_1516 | MSMEG_3532 | Thioredoxin reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00072; match to protein family HMM PF01266; match to protein family HMM PF07992. | Identified by match to protein family HMM PF00291. | 0.444 |
| ABK72676.1 | ABK73847.1 | MSMEG_1516 | MSMEG_5124 | Thioredoxin reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00072; match to protein family HMM PF01266; match to protein family HMM PF07992. | 2,4-dienoyl-coA reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00724; match to protein family HMM PF03486; match to protein family HMM PF07992. | 0.657 |
| ABK72676.1 | bioF | MSMEG_1516 | MSMEG_3189 | Thioredoxin reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00072; match to protein family HMM PF01266; match to protein family HMM PF07992. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.852 |
| ABK72676.1 | gcvP | MSMEG_1516 | MSMEG_3642 | Thioredoxin reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00072; match to protein family HMM PF01266; match to protein family HMM PF07992. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.913 |
| ABK72676.1 | glyA | MSMEG_1516 | MSMEG_5249 | Thioredoxin reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00072; match to protein family HMM PF01266; match to protein family HMM PF07992. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.478 |
| ABK72676.1 | ltaE | MSMEG_1516 | MSMEG_4454 | Thioredoxin reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00072; match to protein family HMM PF01266; match to protein family HMM PF07992. | L-threonine aldolase, low-specificity; Identified by similarity to SP:O50584; match to protein family HMM PF00282; match to protein family HMM PF01212. | 0.775 |
| ABK73847.1 | ABK72676.1 | MSMEG_5124 | MSMEG_1516 | 2,4-dienoyl-coA reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00724; match to protein family HMM PF03486; match to protein family HMM PF07992. | Thioredoxin reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00072; match to protein family HMM PF01266; match to protein family HMM PF07992. | 0.657 |
| ABK73847.1 | bioF | MSMEG_5124 | MSMEG_3189 | 2,4-dienoyl-coA reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00724; match to protein family HMM PF03486; match to protein family HMM PF07992. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.741 |
| ABK73847.1 | gcvP | MSMEG_5124 | MSMEG_3642 | 2,4-dienoyl-coA reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00724; match to protein family HMM PF03486; match to protein family HMM PF07992. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.949 |
| ABK73847.1 | gcvT | MSMEG_5124 | MSMEG_4278 | 2,4-dienoyl-coA reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00724; match to protein family HMM PF03486; match to protein family HMM PF07992. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.749 |
| ABK73847.1 | glyA | MSMEG_5124 | MSMEG_5249 | 2,4-dienoyl-coA reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00724; match to protein family HMM PF03486; match to protein family HMM PF07992. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.745 |
