Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ABK74034.1GAF domain, putative; Identified by match to protein family HMM PF01590. (165 aa)    
Predicted Functional Partners:
ABK75795.1
Two-component system sensor kinase; Identified by match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF07730; match to protein family HMM TIGR00229.
   
 0.758
metH
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.561
ABK69658.1
Two-component sensor protein; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF05227.
    
 0.552
ABK71667.1
Monoxygenase.
       0.541
ssuD-6
Nitrilotriacetate monooxygenase component A; Identified by match to protein family HMM PF00296.
       0.541
ribBA
Riboflavin biosynthesis protein ribAB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
    
  0.498
ABK71907.1
Putative cyclase; Identified by match to protein family HMM PF00211; match to protein family HMM PF00672.
  
 
 0.468
leuS
leucyl-tRNA synthetase; Identified by match to protein family HMM TIGR00396; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 
 0.427
guaA
Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
  0.426
ABK75395.1
Conserved hypothetical protein.
  
    0.422
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
Server load: low (22%) [HD]