Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
ABK76006.1Conserved hypothetical protein; Identified by match to protein family HMM PF00296. (318 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.936
ABK70844.1
Conserved hypothetical protein; Identified by match to protein family HMM PF00296.
  
  
  0.908
ABK72595.1
5,10-methylenetetrahydromethanopterin reductase; Identified by match to protein family HMM PF00296.
  
  
  0.818
ABK72350.1
Identified by match to protein family HMM PF02515; Belongs to the CoA-transferase III family.
  
    0.797
ABK71062.1
methylmalonyl-CoA mutase C-terminal domain protein; Identified by match to protein family HMM PF02310; match to protein family HMM TIGR00640.
  
    0.795
ABK75450.1
Conserved hypothetical protein; Identified by match to protein family HMM PF00296.
  
  
 0.778
ABK72828.1
Conserved hypothetical protein.
  
     0.747
ABK74000.1
Conserved hypothetical protein; Identified by match to protein family HMM PF00296.
  
    0.741
ABK71322.1
Conserved hypothetical protein; Identified by match to protein family HMM PF00296.
  
     0.732
ABK72224.1
5,10-methylenetetrahydromethanopterin reductase; Identified by match to protein family HMM PF00296.
  
  
  0.723
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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