| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABK74721.1 | ABK75325.1 | MSMEG_3634 | MSMEG_1603 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304; Belongs to the IMPDH/GMPR family. | 0.972 |
| ABK74721.1 | guaA | MSMEG_3634 | MSMEG_1610 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| ABK74721.1 | guaB | MSMEG_3634 | MSMEG_1602 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.971 |
| ABK74721.1 | ndk | MSMEG_3634 | MSMEG_4627 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.438 |
| ABK74721.1 | purA | MSMEG_3634 | MSMEG_0759 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.986 |
| ABK74721.1 | purH | MSMEG_3634 | MSMEG_5515 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.993 |
| ABK74721.1 | rdgB | MSMEG_3634 | MSMEG_4899 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.966 |
| ABK74721.1 | rph | MSMEG_3634 | MSMEG_4901 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.462 |
| ABK74721.1 | surE | MSMEG_3634 | MSMEG_6820 | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | Acid phosphatase SurE; Identified by match to protein family HMM PF01975; match to protein family HMM TIGR00087. | 0.946 |
| ABK75325.1 | ABK74721.1 | MSMEG_1603 | MSMEG_3634 | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304; Belongs to the IMPDH/GMPR family. | Identified by match to protein family HMM PF00478; match to protein family HMM PF00571; match to protein family HMM TIGR01303. | 0.972 |
| ABK75325.1 | guaA | MSMEG_1603 | MSMEG_1610 | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304; Belongs to the IMPDH/GMPR family. | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| ABK75325.1 | guaB | MSMEG_1603 | MSMEG_1602 | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304; Belongs to the IMPDH/GMPR family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.989 |
| ABK75325.1 | ndk | MSMEG_1603 | MSMEG_4627 | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304; Belongs to the IMPDH/GMPR family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.414 |
| ABK75325.1 | purA | MSMEG_1603 | MSMEG_0759 | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304; Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.989 |
| ABK75325.1 | purH | MSMEG_1603 | MSMEG_5515 | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304; Belongs to the IMPDH/GMPR family. | Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.994 |
| ABK75325.1 | rdgB | MSMEG_1603 | MSMEG_4899 | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304; Belongs to the IMPDH/GMPR family. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.953 |
| ABK75325.1 | rph | MSMEG_1603 | MSMEG_4901 | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304; Belongs to the IMPDH/GMPR family. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.408 |
| ABK75325.1 | surE | MSMEG_1603 | MSMEG_6820 | Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304; Belongs to the IMPDH/GMPR family. | Acid phosphatase SurE; Identified by match to protein family HMM PF01975; match to protein family HMM TIGR00087. | 0.944 |
| dut | ndk | MSMEG_2765 | MSMEG_4627 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.989 |
| dut | rdgB | MSMEG_2765 | MSMEG_4899 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.972 |
