Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ABK74454.1methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (165 aa)    
Predicted Functional Partners:
ABK70918.1
Transcriptional regulator, Ada family protein/DNA-3-methyladenine glycosylase II; Identified by match to protein family HMM PF00165; match to protein family HMM PF00730; match to protein family HMM PF02805; match to protein family HMM PF06029.
 
 0.852
tag
DNA-3-methyladenine glycosylase I; Identified by match to protein family HMM PF03352; match to protein family HMM TIGR00624.
   
 0.775
ABK69693.1
Cobyrinic Acid a,c-diamide synthase; Identified by match to protein family HMM PF01656.
 
    0.578
ABK74964.1
Soj family protein; Identified by match to protein family HMM PF01656.
 
    0.572
ABK73719.1
IS1096, tnpR protein; Identified by similarity to GP:150004; match to protein family HMM PF07929.
       0.559
soj
SpoOJ regulator protein; Identified by match to protein family HMM PF01656.
 
    0.558
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 
 
 0.527
galT
Galactose-1-phosphate uridylyltransferase; Identified by match to protein family HMM PF01087; match to protein family HMM PF02744; match to protein family HMM TIGR00209.
  
  
 0.490
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function (By similarity). Also inhibits the diadenylate cyclase activity of DisA ; Belongs to the Rec [...]
     
 0.489
ABK73674.1
ParB-like partition proteins; Identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; Belongs to the ParB family.
 
    0.470
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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