Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ABK72356.1Drug resistance transporter Bcr/CflA subfamily protein; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710. (417 aa)    
Predicted Functional Partners:
ABK71409.1
Chloramphenicol resistance protein; Identified by match to protein family HMM PF06779; match to protein family HMM PF07690.
  
   
 0.848
ABK74430.1
Tetracycline-resistance determinant TetV; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00900.
      
 0.820
ABK70840.1
Drug transporter; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; Belongs to the major facilitator superfamily.
 
   
0.615
ABK74759.1
Conserved hypothetical protein; Identified by match to protein family HMM PF02622; Belongs to the UPF0301 (AlgH) family.
      
 0.530
ABK75232.1
Conserved hypothetical protein.
       0.513
lfrA
Proton antiporter efflux pump; Energy-dependent efflux pump that contributes to drug resistance. Catalyzes the efflux of norfloxacin and several related fluoroquinolones (FQ). Contributes significantly to the intrinsic MICs for ethidium bromide and acriflavine. Overexpression confers low-level resistance to hydrophilic FQ such as ciprofloxacin, ofloxacin and levofloxacin, and to ethidium bromide, acridine, acriflavine, rhodamine 123 and some quaternary ammonium compounds. May contribute to resistance to certain beta-lactams. Probably uses the proton motive force.
  
   
 0.476
sucA
2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...]
  
 
 0.463
ABK74213.1
Transmembrane efflux pump; Identified by match to protein family HMM PF07690.
  
   
 0.441
ABK70138.1
Identified by match to protein family HMM PF07690.
  
   
 0.411
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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