STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABK70704.1ABC transporter ATP-binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664. (638 aa)    
Predicted Functional Partners:
ABK73842.1
ABC transporter, ATP-binding protein GluA; Identified by match to protein family HMM PF00005.
   
0.831
ABK71894.1
ABC transporter ATP-binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664.
 
  
0.798
ABK71841.1
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664.
 
  
0.777
prrA
DNA-binding response regulator PrrA; Identified by similarity to SP:Q10531; match to protein family HMM PF00072; match to protein family HMM PF00486.
  
  
 0.777
mpa
ATPase, AAA family protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
  
 0.740
ABK71537.1
Valosin containing protein-1; Identified by match to protein family HMM PF00004; Belongs to the AAA ATPase family.
 
 
 0.684
ABK69664.1
Glutamine ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
     
0.680
ABK74364.1
ABC transporter ATP-binding protein; Identified by match to protein family HMM PF00005.
 
 0.679
prcB
Proteasome beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.smegmatis proteasome is able to cleave oligopeptides after hydrophobic residues, thus displaying chymotrypsin-like activity. In complex with the ATPase Mpa, degrades protein targets conjugated to a prokaryotic ubiquitin- like protein (Pup). Among the identified substrates of the M.smegmatis proteasome are the pupylated SodA and Ino1 proteins. The Pup-proteasome system (PPS) is essential for survival under starvation; PPS likely functions to r [...]
  
 0.670
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.668
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.