STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ksdD3-ketosteroid dehydrogenase; Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids. Is also involved in the formation of 1,4-androstadiene-3,17-dione (ADD) from 4-androstene-3,17-dione (AD) to. (569 aa)    
Predicted Functional Partners:
kshA
Rieske [2Fe-2S] domain protein; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost- 1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A.
 
 
 0.996
kshB
Oxidoreductase, electron transfer component; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost- 1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A.
 
 
 0.989
ABK70591.1
Oxygenase KshA; Identified by match to protein family HMM PF00355.
 
 
 0.988
ABK73925.1
Steroid delta-isomerase; Identified by match to protein family HMM PF02136.
 
 
 0.944
ABK71225.1
Nuclear transport factor 2 (NTF2) domain superfamily protein; Identified by match to protein family HMM PF02136.
 
  
 0.941
ABK75596.1
Putative peroxisomal multifunctional enzyme type 2; Identified by match to protein family HMM PF01575.
 
  
 0.938
ABK74503.1
Succinate dehydrogenase; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266.
 
  
0.936
ABK71760.1
3-ketosteroid-delta4; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266.
 
 
 
0.932
ABK72155.1
Oxidoreductase, NAD/FAD-binding; Identified by match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970.
 
 
 0.928
ABK71264.1
Hypothetical protein; Identified by Glimmer2; putative.
    
 0.906
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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