node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
clgR | clpC1 | MSMEG_2694 | MSMEG_6091 | Transcriptional regulator, XRE family protein; Probably controls the response to vancomycin treatment; vancomycin induces expression of the clp regulon (clpP1, clpP2 and clpC1). | Negative regulator of genetic competence ClpC/mecB; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable); Belongs to the ClpA/ClpB family. ClpC subfamily. | 0.838 |
clgR | clpP | MSMEG_2694 | MSMEG_4672 | Transcriptional regulator, XRE family protein; Probably controls the response to vancomycin treatment; vancomycin induces expression of the clp regulon (clpP1, clpP2 and clpC1). | Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.419 |
clgR | clpP-2 | MSMEG_2694 | MSMEG_4673 | Transcriptional regulator, XRE family protein; Probably controls the response to vancomycin treatment; vancomycin induces expression of the clp regulon (clpP1, clpP2 and clpC1). | Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.810 |
clgR | clpS | MSMEG_2694 | MSMEG_4910 | Transcriptional regulator, XRE family protein; Probably controls the response to vancomycin treatment; vancomycin induces expression of the clp regulon (clpP1, clpP2 and clpC1). | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.591 |
clgR | clpX | MSMEG_2694 | MSMEG_4671 | Transcriptional regulator, XRE family protein; Probably controls the response to vancomycin treatment; vancomycin induces expression of the clp regulon (clpP1, clpP2 and clpC1). | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.564 |
clpC1 | clgR | MSMEG_6091 | MSMEG_2694 | Negative regulator of genetic competence ClpC/mecB; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable); Belongs to the ClpA/ClpB family. ClpC subfamily. | Transcriptional regulator, XRE family protein; Probably controls the response to vancomycin treatment; vancomycin induces expression of the clp regulon (clpP1, clpP2 and clpC1). | 0.838 |
clpC1 | clpP | MSMEG_6091 | MSMEG_4672 | Negative regulator of genetic competence ClpC/mecB; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable); Belongs to the ClpA/ClpB family. ClpC subfamily. | Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.995 |
clpC1 | clpP-2 | MSMEG_6091 | MSMEG_4673 | Negative regulator of genetic competence ClpC/mecB; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable); Belongs to the ClpA/ClpB family. ClpC subfamily. | Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.993 |
clpC1 | clpS | MSMEG_6091 | MSMEG_4910 | Negative regulator of genetic competence ClpC/mecB; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable); Belongs to the ClpA/ClpB family. ClpC subfamily. | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.935 |
clpC1 | clpX | MSMEG_6091 | MSMEG_4671 | Negative regulator of genetic competence ClpC/mecB; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable); Belongs to the ClpA/ClpB family. ClpC subfamily. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.920 |
clpC1 | dnaJ-2 | MSMEG_6091 | MSMEG_4504 | Negative regulator of genetic competence ClpC/mecB; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable); Belongs to the ClpA/ClpB family. ClpC subfamily. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.768 |
clpC1 | dnaK | MSMEG_6091 | MSMEG_0709 | Negative regulator of genetic competence ClpC/mecB; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable); Belongs to the ClpA/ClpB family. ClpC subfamily. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.854 |
clpC1 | groS | MSMEG_6091 | MSMEG_1582 | Negative regulator of genetic competence ClpC/mecB; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable); Belongs to the ClpA/ClpB family. ClpC subfamily. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.759 |
clpC1 | grpE | MSMEG_6091 | MSMEG_0710 | Negative regulator of genetic competence ClpC/mecB; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable); Belongs to the ClpA/ClpB family. ClpC subfamily. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.905 |
clpC1 | panD | MSMEG_6091 | MSMEG_0021 | Negative regulator of genetic competence ClpC/mecB; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable); Belongs to the ClpA/ClpB family. ClpC subfamily. | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.829 |
clpP | clgR | MSMEG_4672 | MSMEG_2694 | Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Transcriptional regulator, XRE family protein; Probably controls the response to vancomycin treatment; vancomycin induces expression of the clp regulon (clpP1, clpP2 and clpC1). | 0.419 |
clpP | clpC1 | MSMEG_4672 | MSMEG_6091 | Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Negative regulator of genetic competence ClpC/mecB; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable); Belongs to the ClpA/ClpB family. ClpC subfamily. | 0.995 |
clpP | clpP-2 | MSMEG_4672 | MSMEG_4673 | Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.998 |
clpP | clpS | MSMEG_4672 | MSMEG_4910 | Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.790 |
clpP | clpX | MSMEG_4672 | MSMEG_4671 | Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.999 |